A Sporadic Parkinson's Disease Model via Silencing of the Ubiquitin- Proteasome/e3-ligase Component, Skp1a
نویسندگان
چکیده
PROTEASOME/E3-LIGASE COMPONENT, SKP1A Tali Fishman-Jacob, Lydia Reznichenko, Moussa BH Youdim and Silvia A Mandel From the Eve Topf and US NPF Centers for Neurodegenerative diseases and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel. Running title: A sporadic Parkinson's disease model via SPK1A silencing Address correspondence to: Dr Silvia Mandel, Department of Molecular Pharmacology, Faculty of Medicine, Technion, P.O.B. 9697, 31096 Haifa, Israel. Tel: +972-4-8295289; Fax: +972-4-8513145, E-mail: [email protected]
منابع مشابه
A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A.
The aim of this study was to develop a new model of sporadic Parkinson disease (PD) based on silencing of the SKP1A gene, a component of the ubiquitin-proteasome/E3 ligase complex, Skp1, Cullin 1, F-box protein, which was found to be highly decreased in the substantia nigra of sporadic PD patients. Initially, an embryonic mouse substantia nigra-derived cell line (SN4741 cells) was infected with...
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